Dr. Daniel Wüthrich
Applied Microbiology Research, Lab 315
Tel: +41 612652323
Since 10/2017: Research Associate, Department Biomedicine, University Basel
05/2016 – 10/2017 Postdoc, Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern
05/2012 – 05/2016 PhD student, Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern
The invention of next generation sequencing (NGS) broad genome research to a new level. It is the first technology that allows the sequencing of whole genomes within a few days. Using NGS, we are able to go beyond single genomes and are now capable of extending our research to whole populations. In particular microbiology prospered under its influence and made a huge step forward in the last years. Studies including hundreds of bacterial genomes are now published by research groups world-wide and show the genomic variability and plasticity within particular species. NGS also gave rise to new fields like metagenomics and changed the way we see complex microbiomes and allows the detection of unknown or uncultivatable organisms.
In the last years, I have been working in various projects and experienced the wide spectrum of the possibilities this innovative technology brings. Among other projects, I studied the evolutionary dynamics of virulence factors in bacterial populations and performed metagenomics in order to find new pathogens. Thereby I found that NGS is a powerful tool for clinical research, epidemiology and experimental diagnostics. The newest trends show that NGS does not only stay in research, but also enters the clinics in the diagnostics. My main focus now is to assists this new development by establishing NGS in a clinical environment in order to help patients with more precious and personalized diagnoses and the public health by setting it into epidemiologic context.